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The Potential Anti-Inflammatory Properties of C60

One of the supposed health benefits of C60 is its anti-inflammatory properties. Several first-hand accounts and user testimonials swear by taking c60 olive oil for inflammation, citing visible results in a few weeks. While there is yet to by any solid scientific evidence to back up this claim, several studies conducted over the past decade or so have delved into this meaty topic. We picked three studies that pose potential explanations for the effect C60 has on inflammation, and how it can help lessen the symptoms.

What Is Inflammation?

Inflammation is often characterized by redness and swelling in the affected area (typically the joints). The area is also often warm to the touch and can be quite stiff. Pain and loss of function are also some symptoms of inflammation. It is primarily a self-defense mechanism that is triggered when the body senses damaged cells or malicious foreign agents. Inflammation is meant to prevent further harm by eliminating the source of the danger and jumpstarting the healing process.

Unfortunately, chronic inflammation or inflammation extended for prolonged periods of time can cause more harm than good.

Suppress Inflammatory Response

In 2013, a study proposing using C60 as a potential novel treatment for intervertebral disc degeneration was published. It looked into C60’s apparent ability suppress the inflammatory response during injury. As mentioned, inflammation is a self-defense mechanism against injury or infection. It’s a conditioned biological response that happens when the body detects damaged cells or malicious foreign agents, and inflammation of the affected area is expected to help the body heal itself and keep out whatever is causing the damage.

According to the study, fullerol nanoparticles (C60) may actually be capable of suppressing that natural inflammatory response.

Shifts Immune Response

A more recent 2016 study focused on the latent anti-inflammatory properties of fullerene C60 by using mice as models of atopic dermatitis (skin inflammation). The researchers first induced skin inflammation in the mice. Once the inflammation set in, they were treated with a water-soluble form of fullerene C60 over a 50-day period. The C60 was administered using both subcutaneous (under the skin) and epicutaneous (on the skin).

The results indicated that both forms of treatment had a therapeutic effect. It was, however, more pronounced (and thus more effective) with the epicutaneous administration. The researchers thereby concluded that a C60 treatment actually shifts the immune response from Th2 (Type 2 helper cell; produces immune responses against extracellular parasites) to Th1 (Type 1 helper cell; generate responses against intracellular parasites), restoring to some extent the function of the skin barrier.

Unlike the previous 2013 study that suggests C60 can inhibit inflammation to a degree, this study suggests that C60 is anti-inflammatory because it shifts the body’s response to cells that won’t cause too much damage over longer periods of time.

Inhibits Degrading Enzymes

While not strictly focused on anti-inflammation, a 2007 study on cartilage biology explores the latent ability of water-soluble C60 fullerene to prevent degeneration of articular cartilage during osteoarthritis. Their results indicated that C60 is, indeed, capable of inhibiting the catabolic stress-induced production of matrix-degrading enzymes. This suggests that C60 can combat inflammation simply by inhibiting the distress signal that triggers the body to react i.e., inhibiting cellular degradation.

Without the articular cartilage breaking down, the body isn’t prompted to release its biological response (inflammation) against damaged cells. Ergo, there is a possibility that C60 can take out inflammation by inhibiting the root cause itself rather than the symptoms.

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